Vibsanin B Preferentially Targets HSP90β, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis
- Bai-Xin Ye, Xu Deng, Zhu Chen
- Biology, MedicineJournal of Immunology
- 1 May 2015
It is demonstrated that vibsanin B ameliorates experimental autoimmune encephalomyelitis in mice with pathological manifestation of decreased leukocyte infiltration into their CNS and is a promising drug lead for treating inflammation-associated diseases.
Macahydantoins A and B, two new thiohydantoin derivatives from Maca (Lepidium meyenii): Structural elucidation and concise synthesis of macahydantoin A
- Mu-Yuan Yu, Xu-Jie Qin, M. Qiu
- 26 April 2017
Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B.
- Jun Xu, Li-Dong Shao, C. Xia
- ChemistryJournal of the American Chemical Society
- 17 December 2014
A facile and straightforward method was developed to construct the fused tetracyclic 3-spirooxindole skeleton, which exists widely in natural products and two potentially medicinal natural products, (±)-corynoxine and (±) Corynoxine B, were efficiently synthesized in five scalable steps.
Bioactive triterpenoids from Sambucus javanica Blume
- Fei-Long Chen, Dongqian Liu, Wenjuan Wang
- ChemistryNatural Product Research
- 10 April 2019
A new triterpene, javablumine A along with six known ones were isolated from the aerial parts of Sambucus javanica Blume and exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.
Vibsane‐Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities
- Qinfeng Zhu, Yan-Yan Qi, Qin‐Shi Zhao
- ChemistryChemistry and Biodiversity
- 1 May 2018
Four new vibsane‐type diterpenoids and a new natural product, 5,6‐dihydrovibsanin B, as well as six known analogues, were isolated from the twigs and leaves of Viburnum odoratissimum and their structures were elucidated by spectroscopic analyses and chemical derivatization method.
One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels-Alder Reaction.
- Luosheng Wan, Li-Dong Shao, M. Qiu
- ChemistryOrganic Letters
- 19 January 2016
In an in vitro activity test, 1 exhibited moderate anti-inflammatory activity, whereas both its precursor (2) and the relevant intermediate (2a, IC50 = 1.56 μM) exhibited significant anti- inflammatory activity.
Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense.
- Xuan-qin Chen, Li-Dong Shao, Qin‐Shi Zhao
- ChemistryJournal of Natural Products
- 1 February 2015
Hupehenols A-E (1-5) showed inhibition against human 11β-HSD1, with hupehenols B and E (5) having IC50 values of 15.3 and 34.0 nM, respectively, which indicated that compounds 1-5 are new 20,21,22,23,25,26,27-octanordammarane triterpenoids.
neo-Clerodanes from the aerial parts of Salvia leucantha
- Yong-jun Jiang, J. Su, Qin‐Shi Zhao
- 1 September 2016
Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus.
- Xiu Gao, Li-Dong Shao, Qin‐Shi Zhao
- ChemistryOrganic Letters
- 7 February 2014
Vibsatins A (1) and B (2), a pair of 14,15,16,17-tetranorvibsane-type diterpenoids that feature a bicyclo[4.2.1]nonane moiety formed by a new C-13/C-2 bond, were isolated from the twigs and leaves of…