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- Roel G W Verhaak, Katherine A Hoadley, +30 authors D. Neil Hayes
- Cancer cell
- 2010
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe a robust gene expression-based molecular classification of GBM into… (More)
- Timothy J. Ley, Li Ding, +45 authors Richard K. Wilson
- The New England journal of medicine
- 2010
BACKGROUND
The genetic alterations responsible for an adverse outcome in most patients with acute myeloid leukemia (AML) are unknown.
METHODS
Using massively parallel DNA sequencing, we identified… (More)
- Ken Chen, John W. Wallis, +13 authors Elaine R. Mardis
- Nature Methods
- 2009
Detection and characterization of genomic structural variation are important for understanding the landscape of genetic variation in human populations and in complex diseases such as cancer. Recent… (More)
- Houtan Noushmehr, Daniel J. Weisenberger, +24 authors Kenneth D. Aldape
- Cancer cell
- 2010
We have profiled promoter DNA methylation alterations in 272 glioblastoma tumors in the context of The Cancer Genome Atlas (TCGA). We found that a distinct subset of samples displays concerted… (More)
- Cyriac Kandoth, Michael D. McLellan, +16 authors Li Ding
- Nature
- 2013
The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point… (More)
- Elaine R. Mardis, Li Ding, +55 authors Timothy J. Ley
- The New England journal of medicine
- 2009
BACKGROUND
The full complement of DNA mutations that are responsible for the pathogenesis of acute myeloid leukemia (AML) is not yet known.
METHODS
We used massively parallel DNA sequencing to… (More)
- Ryan E Mills, Klaudia Walter, +54 authors Jan O. Korbel
- Nature
- 2011
Genomic structural variants (SVs) are abundant in humans, differing from other forms of variation in extent, origin and functional impact. Despite progress in SV characterization, the nucleotide… (More)
- Li Ding, Timothy J. Ley, +36 authors John F. DiPersio
- Nature
- 2012
Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse, which is associated with clonal evolution at the cytogenetic level. To determine the mutational spectrum… (More)
- John S. Welch, Timothy J. Ley, +51 authors Richard K. Wilson
- Cell
- 2012
Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML),… (More)
- Gang Wu, Alberto Broniscer, +18 authors Suzanne J. Baker
- Nature Genetics
- 2012
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of… (More)