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PURPOSE Implant anchors such as miniscrews and miniplates have been loaded immediately for anchorage during orthodontic treatment. The purpose of this study was to measure the removal torque of immediately loaded miniscrews after clinical usage and to determine the possible factors associated with this value. MATERIALS AND METHODS From 29 patients with(More)
BACKGROUND/PURPOSE Needlestick/sharps injuries (NSI) are a major occupational hazard among healthcare workers. Since needles and sharps are commonly used during dental procedures, workers in the dental profession are especially prone to sharps-related injuries. In this study, NSI among workers in the dental department of National Taiwan University Hospital(More)
The medical equipment industry has been one of the fastest growing sectors of the decade with predicted global sales reaching US$ 430 billion in 2017 [22]. During the period from 1995 to 2008, the patent applications in medical technology increased rapidly worldwide (World Intellectual Property Organization, 2012). Patent analysis, although useful in(More)
After operative restoration, some monomers released from dentin bonding agents or composite resin may induce tissue inflammation and affect the vitality of dental pulp. Whether BisGMA, a major monomer of composite resin, may induce prostaglandin release and cytotoxicity to pulp cells and their mechanisms awaits investigation. We found that BisGMA induced(More)
PURPOSE A 3-dimensional finite element model consisting of a bone block and 2 simulated premolar crowns supported by 2 adjacent cylindric implants without immediately surrounding cortical bone was generated and used to investigate the effects of prosthesis materials and prosthesis splinting on the peri-implant bone stress under static loads. MATERIALS AND(More)
BACKGROUND The role of lipopolysaccharide (LPS) in periapical lesion-induced bone resorption was investigated. Polymyxin B (PMB), a specific inhibitor of LPS, was evaluated to treat the apical lesion. METHODS Lipopolysaccharide isolated from two common endodontic pathogens, Fusobacterium nucleatum and Porphyromonas endodontalis, stimulated mouse(More)
Betel quid (BQ) chewing is an oral habit that increases the risk of oral cancer and oral submucous fibrosis (OSF), a precancerous condition showing epithelial atrophy and tissue fibrosis. Persistent fibroblast contraction may induce the fibrotic contracture of tissue. In this study, we found that areca nut extract (ANE) (200-1200 µg/ml) stimulated buccal(More)
INTRODUCTION Autophagy is a process for recycling intracellular organelles as a survival mechanism. Apoptosis has important biological roles in the pathogenesis of many diseases. This study elucidated the effect of simvastatin on autophagy/apoptosis in MC3T3E1 murine osteoblastic cells and also the significance of this action on the progression of induced(More)
OBJECTIVE To examine the role of sirtuin-1 (SIRT-1)/FoxO3a in the expression of cysteine-rich protein 61 (CYR-61) in rheumatoid arthritis synovial fibroblasts (RASFs) and the influence of simvastatin on this pathway, and to determine the relationship between disease progression and FoxO3a/CYR-61 signaling in synovial fibroblasts in vivo using a rat model of(More)
Monomers released from resin-containing products may cause various adverse effects. Urethane dimethacrylate (UDMA) is a principal resin monomer and also a major component released from various dental resin materials. Thus the toxic effects and mechanisms should be elucidated for improving of its safety use. Here we investigated the effects of UDMA on the(More)