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We have constructed a reagentless lactate sensor using lactate oxidase (LOD) covalently attached to an electropolymerized copolymer film, poly(5-hydroxy-1,4-naphthoquinone-co-5-hydroxy-3-thioacetic acid-1,4-naphthoquinone), poly(JUG-co-JUGA). Around 10(-12)Mcm(-2) of covalently bound enzymes are immobilized on these films. In aerated medium, the(More)
Our previous studies have shown that the baicalin could blocked infection of chlamydia trachomatis (C. trachomatis)-infected cells in vitro. Toll-like receptor 2 and 4 (TLR2/4) and the downstream nuclear factor-κB (NF-κB) signaling pathway, which mediate the inflammatory reaction, are involved in the pathophysiological processes of inflammation. In this(More)
An electrochemical hybridization biosensor based on peptide nucleic acid (PNA) probe is presented. PNA were attached covalently onto a quinone-based electroactive polymer. Changes in flexibility of the PNA probe strand upon hybridization generates electrochemical changes at the polymer-solution interface. A reagentless and direct electrochemical detection(More)
In this paper, we present a new improved Active Shape Model (ASM) for facial feature points extraction. ASM performance is often influenced by some factors such as initial position, illumination, pose, etc, which frequently lead to the local minima in optimization. The original ASM has two sub-models: global shape model and local texture model, we proposed(More)
A simple but effective copper-catalyzed borylation of aryl halides, including electron-rich and sterically hindered aryl bromides, with alkoxy diboron reagents occurs under mild conditions (see scheme). Preliminary DFT studies of the mechanism suggest that sigma-bond metathesis between a copper-boryl intermediate and the aryl halide generates the aryl(More)
ERP systems have become the system of choice for the majority of publicly traded companies and have radically changed the way accounting information is processed, prepared, audited, and disseminated. In this study, we examine whether ERP system implementations have affected the extent to which firms manage earnings amounts and release dates. We find, for a(More)
In this feature article, we discuss selected recent aspects of metal boryl (M-BR2) chemistry pertaining, in particular, to the role of late and post-transition metal boryl complexes in various catalytic processes. The exceptionally strong sigma-donor properties of boryl ligands and their related nucleophilic behaviour are highlighted.
PURPOSE Low temperature (hypothermia) during irradiation of cells has been reported to have a radioprotective effect. The mechanisms are not fully understood. This study further investigates the possible mechanisms behind hypothermia-mediated radioprotection. MATERIALS AND METHODS Human lymphoblastoid TK6 cells were incubated for 20 min at 0.8 or 37°C and(More)
A system device using multifunctional conjugated copolymer poly(5-hydroxy-1,4-naphthoquinone-co-hydroxy-2-thioacetic acid-1,4-naphthoquinone) acting both as immobilizing and transducing element for reagentless immunosensor has been constructed. Its functionality was evaluated in an antigen-antibody interaction model using ovalbumin-anti-ovalbumin. It was(More)
DFT calculations have been carried out to investigate the reaction mechanism for Pd(II)-mediated enantioselective C-H iodination. Iodination of the aryl ortho C-H bond of benzylamines catalyzed by Pd(II) diacetate complexes in the presence of the L-MPAA ligand experiences three main steps: first, C-H bond activation; second, oxidative addition of iodine on(More)