Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines
- C. Wen, Hui‐ming Chen, N. Yang
- Biology, MedicineJournal of Biomedical Sciences
- 20 June 2011
Specific MDAs including the clinical drug, colchicine, can induce immunogenic cell death in tumor cells, and DCs pulsed with MDA-treated tumor cell lysates (TCLs) can generate potent anti-tumor immunity in mice.
Synthesis of 1-benzyl-3-(5-hydroxymethyl-2-furyl)selenolo[3,2-c]pyrazole derivatives as new anticancer agents.
- Li-Chen Chou, Li‐Jiau Huang, S. Kuo
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 1 April 2010
Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.
- Li-Chen Chou, Chien‐Ting Chen, S. Kuo
- Chemistry, BiologyJournal of Medicinal Chemistry
- 25 February 2010
Compound 4 was rapidly converted into 1 following iv and po administration and also possessed excellent antitumor activity in a SKOV-3 xenograft nude mice model and is highly promising for development as an anticancer clinical trials candidate.
Frequency doubling technology perimetry in age-related macular degeneration.
- S. Sheu, Ying-ying Chen, Li-Chen Chou, Tsung‐Tien Wu, Kwok-Kei Cheng
- MedicineZhonghua yi xue za zhi = Chinese medical journal…
- 1 September 2002
The results suggest that FDT using full-threshold C-20 mode is not sensitive enough for the detection of small macular lesions in ARMD, and might not be a useful functional evaluation in AR MD.
Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents.
- Li-Chen Chou, Meng-Tung Tsai, S. Kuo
- Chemistry, BiologyJournal of Medicinal Chemistry
- 25 October 2010
Sodium 2-(3-fluorophenyl)-5-hydroxy-6-methoxy-4-oxo-1,4-dihydroquinolin-5-yl phosphate (15), the monophosphate of 3b, exceeded the activity of doxorubicin and was comparable to CHM-1-P-Na in a Hep3B xenograft nude mice model.
Synthesis of furopyrazole analogs of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole (YC-1) as novel anti-leukemia agents.
- Li-Chen Chou, Li‐Jiau Huang, Jai-Sing Yang, F. Lee, C. Teng, S. Kuo
- Chemistry, BiologyBioorganic & Medicinal Chemistry
- 15 February 2007
Synthesis and anticancer activity of 2,4-disubstituted furo[3,2-b]indole derivatives.
- Shi-Hong Zhuang, Yi-Chien Lin, Li‐Jiau Huang
- ChemistryEuropean journal of medicinal chemistry
- 1 August 2013
Synthesis and SAR studies of novel 6,7,8‐substituted 4‐substituted benzyloxyquinolin‐2(1H)‐one derivatives for anticancer activity
- Yi-Fong Chen, Yi-Chien Lin, Li‐Jiau Huang
- ChemistryBritish Journal of Pharmacology
- 1 March 2015
Four new 4‐Phenylquinolin‐2(1H)‐one derivatives can induce cancer cell apoptosis and were investigated as more effective, less toxic antitumour agents.
Risk factors for endogenous endophthalmitis secondary to Klebsiella pneumoniae liver abscess.
- S. Sheu, Li-Chen Chou, M. Hong, Y. Hsiao, Yung-ching Liu
- MedicineZhonghua yi xue za zhi = Chinese medical journal…
- 1 November 2002
The visual prognosis of endogenous endophthalmitis secondary to Klebsiella pneumoniae liver abscess is generally poor, and diabetes might be a significant risk factor for the poor visual outcome.
Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs.
- Chien‐Ting Chen, M. Hsu, S. Kuo
- Chemistry, BiologyEuropean journal of medicinal chemistry
- 1 December 2011
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