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USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1
Investigation of the biological role of a certain lncRNA in cutaneous squamous cell carcinoma found that YAP1, a Hippo pathway factor, was positively regulated by LINC01048, and mechanism investigation revealed that Linc01048 increased the binding of TAF15 to Yap1 promoter to transcriptionally activate YAP 1 in CSCC cells. Expand
AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo.
- Lezi Chen, Quan Chen, +4 authors Huilan Zhu
- Chemistry, Medicine
- Biochemical and biophysical research…
- 25 November 2016
It is shown that targeted activation of AMPK by GSK621 inhibits melanoma cell survival and proliferation, and that MEK-ERK activation might be the primary resistance factor of GSK 621. Expand