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USF1-induced upregulation of LINC01048 promotes cell proliferation and apoptosis in cutaneous squamous cell carcinoma by binding to TAF15 to transcriptionally activate YAP1
TLDR
Investigation of the biological role of a certain lncRNA in cutaneous squamous cell carcinoma found that YAP1, a Hippo pathway factor, was positively regulated by LINC01048, and mechanism investigation revealed that Linc01048 increased the binding of TAF15 to Yap1 promoter to transcriptionally activate YAP 1 in CSCC cells. Expand
AMPK activation by GSK621 inhibits human melanoma cells in vitro and in vivo.
TLDR
It is shown that targeted activation of AMPK by GSK621 inhibits melanoma cell survival and proliferation, and that MEK-ERK activation might be the primary resistance factor of GSK 621. Expand