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HAMLET is a complex of α-lactalbumin (α-LA) with oleic acid (OA) that selectively kills tumor cells and Streptococcus pneumoniae. To assess the contribution of the proteinaceous component to cytotoxicity of HAMLET, OA complexes with proteins structurally and functionally distinct from α-LA were prepared. Similar to HAMLET, the OA complexes with bovine(More)
HAMLET is a complex of human α-lactalbumin (hLA) with oleic acid (OA) that kills various tumor cells and strains of Streptococcus pneumoniae. More potent protein-OA complexes were previously reported for bovine α-lactalbumin (bLA) and β-lactoglobulin (bLG), and pike parvalbumin (pPA), and here we explore their structural features. The concentration(More)
Samples of low-molecular weight chitosan with molecular masses of 8–24 kDa, identical deacetylation degrees (85%), and polydispersity indexes soluble at pH 5–7 were obtained by enzymatic hydrolysis using an enzyme complex from the mycelial fungi Myceliophthora fergusii with yields of 50–80%. The optimal conditions for hydrolysis were found (pH 5.6, 37°C, an(More)
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