Levente Molnar

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BACKGROUND In chronic liver disease, hepatic stellate cells (HSC) transdifferentiate into myofibroblasts, promoting extracellular matrix (ECM) synthesis and deposition. Stimulation of HSC by transforming growth factor-β (TGF-β) is a crucial event in liver fibrogenesis due to its impact on myofibroblastic transition and ECM induction. In contrast, hepatocyte(More)
The therapeutic and diagnostic problems of colorectal cancers in young adults (under the age of 40 years) are discussed, with special considerations to the unfavourable prognosis and its underlying causes. At the Department of Surgery, National Institute of Oncology, Altogether 638 patients were treated for colorectal cancer in the course of 10 years(More)
BACKGROUND Despite technical advancements, implantation of coronary sinus (CS) leads may be challenging, and dislocation remains a relevant clinical problem. OBJECTIVE The aim of this study was to investigate the effectiveness, safety, and long-term outcome of stent implantation to anchor the lead to the wall of the CS side branch. METHODS Stenting of a(More)
BACKGROUND The GIHU004 study was designed to evaluate the safety and immunogenicity of three doses of DermaVir immunization in HIV-infected subjects on fully suppressive combination antiretroviral therapy (cART). METHODOLOGY/PRINCIPAL FINDINGS This first-in-human dose escalation study was conducted with three topical DermaVir doses targeted to epidermal(More)
Subclavian artery puncture and dilation with 9 Fr dilator during pacemaker implantation is a rare complication. We present a case, where this complication occurred and the injury was sealed with collagen-based closure device without any complications. Long term follow-up and the control angio-CT revealed no further late vascular complications. Therefore,(More)
AIMS Phrenic nerve stimulation (PNS), which is often intolerable for the patient, is a known complication of resynchronization therapy. We describe a new, minimal invasive method for treating PNS. METHODS AND RESULTS Untreatable PNS was found in nine cardiac resynchronization therapy patients with distal coronary sinus (CS) lead position 6 +/- 6 (0.5-17)(More)
AIM Failure rate to implant left ventricular (LV) lead transvenously is 4-8% in cardiac resynchronization therapy (CRT) patients. Epicardial lead placement is an alternative method and if not applicable case reports and small series showed the feasibility of endocardial LV lead implantation. Electroanatomical mapping might be a useful tool to guide this(More)
We report the results obtained during the verification of Autosub6000, an autonomous underwater vehicle used for deep oceanic exploration. Our starting point is the Simulink/Matlab engineering model of the submarine, which is discretised by a compiler into a representation suitable for model checking. We assess the ability of the vehicle to function under(More)
Nine years prior to admission a 33 year old female had suffered a left-sided skull fracture without pyramidal involvement. In the same year she underwent a radical ear operation on the left due to chronic otitis media. Four years later, gradual signs of raised intracranial pressure developed and a communicating hydrocephalus was confirmed by cine-MRT. After(More)