Levente L. Simon

  • Citations Per Year
Learn More
This contribution describes the real time pressure check pattern recognition of an industrial batch dryer. The goal is to identify the start of the drying process and to calculate the time elapsed between two consequent batch starts (batch time) right after the batch has completed. The presented pattern recognition method implements a supervised learning(More)
The contribution of this work deals with the optimization of the temperature profile of a three-phase batch reaction with regard to swelling phenomena. The optimization procedure is carried out in the form of an optimal control problem. The system is modeled using a dynamic first-principles model for the reaction which is linked to a hydrodynamic model.
The contribution of this paper presents a systematic, indicator and process heuristics based retrofit method for batch processes. The developed framework considers the identification of improvement opportunities in a generic batch plant by considering also the product market situation. The evaluation of retrofit actions is performed using dynamic batch(More)
We present an industrial case study of a three-phase reaction system in a batch reactor. For the successful modeling and prediction of the plant-scale performance a hybrid model is used. Data from different scales were available for developing the model. In order to model the large-scale production process the first principles model was extended with neural(More)
Since the 2004 FDA initiative the investigation and evaluation of in-situ process analytical methods (PAT) has been significantly intensified. In the class of PAT tools relevant for the monitoring of crystallization processes belong the spectroscopy based methods which monitor the liquid concentration; an exception is the FT-Raman spectroscopy which is also(More)
The purpose of this work is two fold: it describes the proof of concept of the newly introduced bulk video imaging (BVI) method and it presents the nucleation detection in comparison with existing process analytical technologies (PAT) such as focused beam reflectance measurement (FBRM) and ultra violet/visible (UV/Vis) spectroscopy. While the latter two(More)
This paper presents the application of nonlinear model predictive control (NMPC) to a simulated industrial batch reactor subject to safety and productivity constraints due to swelling. The catalyst used in the chemical process decomposes in the reactor; therefore it is fed in discrete time steps during the batch. Although the optimal reactor temperature(More)
Probiotic microorganisms have been shown to provide specific health benefits when consumed as food supplements or as food components. The main problem of such products is the poor survival of the probiotic bacteria in the low pH of gastric fluid. However the use of synthetic excipients for enteric coating to prevent the exposure of microorganisms to gastric(More)
Complexes of β-cylodextrin with five nucleotides of adenine (A), thymine (T) guanine (G), cytosine (C), and 5-methylcytosine have been investigated using Hatree-Fock (HF) and density functional theory (DFT) calculations of different quality. This work was inspired by recent technological advances made in singlemolecule sequencing of DNA. One molecule of(More)