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Intact brown adipose tissue thermogenesis is required for restorative sleep responses after sleep loss
Metabolic signals related to feeding and body temperature regulation have profound effects on vigilance. Brown adipose tissue (BAT) is a key effector organ in the regulation of metabolism in severalExpand
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The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads toExpand
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Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3
Certain sickness behaviors occur consistently in influenza-infected humans and mice. These include body temperature changes, somnolence, and anorexia. Several cytokines serve as mediators of theExpand
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Butyrate, a metabolite of intestinal bacteria, enhances sleep
Emerging evidence suggests that the intestinal microbiota is a source of sleep-promoting signals. Bacterial metabolites and components of the bacterial cell wall are likely to provide important linksExpand
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Can the therapeutic efficacy of tocotrienols in neurodegenerative familial dysautonomia patients be measured clinically?
Familial dysautonomia (FD) is an inherited, fatal, neurodegenerative disorder manifested by autonomic/hypertensive crises and cardiac instability. Patients produce little IKAP, the gene product ofExpand
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Impaired wake‐promoting mechanisms in ghrelin receptor‐deficient mice
Ghrelin receptors are expressed by key components of the arousal system. Exogenous ghrelin induces behavioral activation, promotes wakefulness and stimulates eating. We hypothesized thatExpand
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Brown adipose tissue plays a central role in systemic inflammation-induced sleep responses
We previously identified brown adipose tissue (BAT) as a source of sleep-inducing signals. Pharmacological activation of BAT enhances sleep while sleep loss leads to increased BAT thermogenesis.Expand
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Brown adipose tissue at the intersection of sleep and temperature regulation
The article demonstrates the importance of brown fat in creating and maintaining a metabolic environment which is permissive for optimal restorative sleep after sleep loss. The authors propose thatExpand
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Sleep and body temperature in TNFα knockout mice: The effects of sleep deprivation, β3-AR stimulation and exogenous TNFα
Increased production of pro-inflammatory cytokines is assumed to mediate increased sleep under inflammatory conditions, such as systemic infections or recovery from sleep loss. The role of cytokinesExpand
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Mice Lacking Alternatively Activated (M2) Macrophages Show Impairments in Restorative Sleep after Sleep Loss and in Cold Environment
The relationship between sleep, metabolism and immune functions has been described, but the cellular components of the interaction are incompletely identified. We previously reported that systemicExpand
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