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Increasing evidence indicates that cancer stem cells have essential roles in tumor initiation, progression, metastasis and resistance to chemo-radiation. Recent research has pointed out biological importance of microRNAs in cancer stem cell dysregulation. Total number of mature microRNAs in human genome increased to more than 2,500 with the recent up-date(More)
Tumor masses are composed of heterogenic subpopulations of cancer cells, and cancer stem cell theory suggests that only a specific subpopulation of these cells has the ability to sustain cancer growth and metastatic activity, whereas all of the other cancer cells have only a limited growth potential or no growth potential at all. Based on this concept in(More)
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