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Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum.
The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to assess theExpand
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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
Our understanding of the key phosphorylation-dependent signalling pathways in the human malaria parasite, Plasmodium falciparum, remains rudimentary. Here we address this issue for the essentialExpand
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Regulation of Casein Kinase-2 (CK2) Activity by Inositol Phosphates*
Casein kinase 2 (CK2) was one of the first protein kinases to be discovered and has been suggested to be responsible for as much as one-fifth of the eukaryotic phosphoproteome. Despite beingExpand
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A Unique Protein Phosphatase with Kelch-Like Domains (PPKL) in Plasmodium Modulates Ookinete Differentiation, Motility and Invasion
Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways,Expand
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A Putative Homologue of CDC20/CDH1 in the Malaria Parasite Is Essential for Male Gamete Development
Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), whichExpand
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Spatiotemporal and Functional Characterisation of the Plasmodium falciparum cGMP-Dependent Protein Kinase
Signalling by 3′–5′-cyclic guanosine monophosphate (cGMP) exists in virtually all eukaryotes. In the apicomplexan parasite Plasmodium, the cGMP-dependent protein kinase (PKG) has previously beenExpand
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Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Targeting parasite's protein kinase Malaria elimination goals are constantly eroded by the challenge of emerging drug and insecticide resistance. Alam et al. have taken established drug targets—CLKExpand
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Regulation of p53 expression, phosphorylation and sub-cellular localisation by a G-protein coupled receptor
G-protein-coupled receptors (GPCRs) have been extremely successful drug targets for a multitude of diseases from heart failure to depression. This superfamily of cell surface receptors have not,Expand
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Experimental tools for the study of protein phosphorylation in Plasmodium.
The central role played by protein phosphorylation in the regulation of eukaryotic cellular processes calls for detailed investigations of this phenomenon in malaria parasites. Here, we describeExpand
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Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation
Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cellExpand
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