Letty G. Briggs

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SUMMARY Fine structural studies that included the use of various enzyme digestion procedures and autoradiography were carried out on ME-180 tissue culture cells treated with actinomycin D. Particular emphasis was placed on the evolution of the nucleolar changes that resulted from treatment with the antibiotic. Degradation of the nucleoloemal structure was(More)
The fine structural effects of camptothecin, a plant alkaloid with known antitumor activity, have been examined in ME-180 tissue culture cells. The drug has recently been shown to inhibit ribosomal RNA synthesis; nucleolar changes were therefore expected to occur. As shown here, camptothecin induces nucleoli to segregate but, in addition, it produces(More)
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