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After block of Kv1- and Kv2-mediated K(+) currents in acutely dissociated neocortical pyramidal neurons from layers II/III of rat somatosensory and motor cortex, the remaining current is slowly activating and persistent. We used whole cell voltage clamp to show that the Kv7 blockers linopirdine and XE-991 blocked a current with similar kinetics to the(More)
Potassium channels regulate numerous aspects of neuronal excitability, and several voltage-gated K(+) channel subunits have been identified in pyramidal neurons of rat neocortex. Previous studies have either considered the development of outward current as a whole or divided currents into transient, A-type and persistent, delayed rectifier components but(More)
Developing countries seeking to expand their exports often turn to food exports and seek to market these products in developed countries such as the United States. To be successful, developing countries must overcome an array of obstacles, including the need to comply with the food safety and other requirements of the importing country. This article(More)
This paper discusses the place of risk analysis in international trade from a US perspective, through looking at the activities of the World Trade Organization and the Codex Alimentarius Commission. After examining what the trade agreements say about risk analysis and how international bodies are advancing and using risk analysis, the paper goes on to(More)
  • L R Horton
  • 1996
The U.S. Food and Drug Administration is increasing its emphasis and participation in international harmonization activities. Forces that have led the agency in this direction include increased trade, the multinational nature of the pharmaceutical industry, trade agreements such as NAFTA and the new GATT World Trade Organization agreement, European(More)