Leslie P. Felpel

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The disynaptic inhibitory pathway from labyrinth to neck motoneurons was investigated pharmacologically in pentobarbitone or chloraloseurethane anesthetized cats. Stimulation of the labyrinth produced disynaptic IPSPs in 85% of third cervical dorsal ramus (DR) motoneurons. Following intravenous strychnine (0.15–0.3 mg/kg), disynaptic IPSPs were recorded(More)
The influence of the cerebellum on the activity of Deiters' cells has been studied by comparing the extracellularly recorded activity of single cells in decerebellate cats and in those with an intact cerebellum. The tonic inhibitory influence of the cerebellum is reflected in three ways: a smaller proportion of those cells projecting to the spinal cord is(More)
The microiontophoretic application of morphine to single globus pallidus neurons in morphine naive rats resulted in a depression of both spontaneous and glutamate-evoked firing of these neurons. Seventy percent of all pallidal neurons on which morphine was tested exhibited some degree of depression of neuronal discharge; no excitatory effect ws observed to(More)
Responses of neurons in the medial ponto-medullary reticular formation to stimulation of vestibular nerves, bilateral pericruciate cortex and several cutaneous points were studied in cerebellectomized cats under chloralose-urethan or pentobarbital anesthesia. Reticulospinal neurons were identified by their antidromic responses to stimulation of cervical or(More)
Surgically implanted osmotic minipumps were used to apply dye or [3H]-muscimol locally to the nucleus ventralis lateralis or globus pallidus of the cat. Extent of distribution of dye or radioactivity was measured from the site of application. A uniform distribution (1.2-2.5 mm) of dye or radioactivity was found lateral, ventral, and posterior to the(More)
Postsynaptic potentials, evoked by lingual or hypoglossal nerve stimulation, were recorded from hypoglossal motoneurons of the cat with glass microelectrodes. Lingual nerve-evoked inhibitory postsynaptic potentials (LIPSPs) were recorded in 98% of hypoglossal motoneurons. Hypoglossal nerve stimulation caused a hyperpolarizing potential following the(More)