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RATIONALE Functional magnetic resonance imaging (fMRI) in rats can non-invasively identify brain regions activated by physiological stimuli and the effects of pharmacological intervention on these responses. OBJECTIVES This study was conducted to investigate the effects of systemic administration of the mu-opioid receptor agonist morphine on whole brain(More)
Receptors for excitatory amino-acid transmitters on nerve cells fall into two main categories associated with non-selective cationic channels, the NMDA (N-methyl-D-aspartate) and non-NMDA (kainate and quisqualate) receptors. Special properties of NMDA receptors such as their voltage-dependent blockade by Mg2+ (refs 3, 4) and their permeability to Na+, K+ as(More)
AIMS Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken into account the effect of oxidative stress on astrocytes, and their contribution to pathology. METHODS We(More)
Congenital heart disease (CHD) is the most prevalent birth defect, affecting nearly 1% of live births; the incidence of CHD is up to tenfold higher in human fetuses. A genetic contribution is strongly suggested by the association of CHD with chromosome abnormalities and high recurrence risk. Here we report findings from a recessive forward genetic screen in(More)
  • Co, J B Jones, Non-Enzymic In, Dunill P Catalysis, Ellis Horwood, Chichesrer +21 others
  • 2010
The acceptance of oxoreductases as catalysts in organic syn-thesis2 has been slowed by the expense of the nicotinamide co-factors required by many of these enzymes. Effective procedures for nicotinamide cofactor recycling have decreased the effective cost of these substances by allowing them to be regenerated in situ.3 The nicotinamide cofactors are,(More)
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