Leslie Abramson

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OBJECTIVE To compare the criteria for Wegener's granulomatosis (WG) of the American College of Rheumatology (ACR) with those of the European League Against Rheumatism/Pediatric Rheumatology European Society (EULAR/PRES) in a cohort of children with WG and other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs), and to describe the(More)
OBJECTIVE To use consensus methods and the considerable expertise contained within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) organization to extend the 3 previously developed treatment plans for moderate juvenile dermatomyositis (DM) to span the full course of treatment. METHODS A consensus meeting was held in Chicago on April(More)
OBJECTIVE There are no validated tools for measuring disease activity in pediatric vasculitis. The Birmingham Vasculitis Activity Score (BVAS) is a valid disease activity tool in adult vasculitis. Version 3 (BVAS v.3) correlates well with physician's global assessment (PGA), treatment decision, and C-reactive protein in adults. The utility of BVAS v.3 in(More)
Autonomic functioning, as measured by baseline heart rates during daytime (DHR) and during sleep (SLHR), was examined in 28 patients with major depressive disorder (MDD), 13 patients with panic disorder (PD), 28 patients with MDD and coexisting PD (MDD + PD), and 19 controls. DHR and SLHR in patients with PD or MDD did not differ from normals. Only the MDD(More)
OBJECTIVE Few data are available regarding the rates of serious adverse events (SAEs) and important medical events (IMEs) outside of product-based registries and clinical trials for juvenile idiopathic arthritis (JIA). The Enhanced Drug Safety Surveillance Project (EDSSP) was developed to pilot a novel system to collect SAEs/IMEs in children with JIA. This(More)
BACKGROUND Herein we describe the history, design, and rationale of the new Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and present the characteristics of patients with juvenile idiopathic arthritis (JIA) enrolled in the first 12 months of operation. METHODS The CARRA Registry began prospectively collecting data in the United(More)
OBJECTIVE Granulomatosis with polyangiitis (Wegener's; GPA) and other antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare in childhood and are sometimes difficult to discriminate. We compared use of adult-derived classification schemes for GPA against validated pediatric criteria in the ARChiVe (A Registry for Childhood(More)
We studied the cardiovascular effect of 0.5 mg of arecoline, a centrally active cholinergic muscarinic agonist, infused over a 3-minute period during the second non-REM (rapid-eye-movement) sleep cycle in 23 patients with major depression. A clear-cut cardioacceleratory response, beginning at the second minute of the 3-minute infusion, and reaching a peak(More)
OBJECTIVE To determine whether adult disease severity subclassification systems for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) are concordant with the decision to treat pediatric patients with cyclophosphamide (CYC). METHODS We applied the European Vasculitis Study (EUVAS) and Wegener's Granulomatosis Etanercept Trial (WGET) disease(More)
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