Lesley S Bechtold

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Mutations within the CRB1 gene have been shown to cause human retinal diseases including retinitis pigmentosa and Leber congenital amaurosis. We have recently identified a mouse model, retinal degeneration 8 (rd8) with a single base deletion in the Crb1 gene. This mutation is predicted to cause a frame shift and premature stop codon which truncates the(More)
Nude mice have a mutation in the transcription factor Foxn1(nu), resulting in downregulation of hair keratins. Although hair follicles develop normally, the hair fibers become structurally weak, curl, and break off at the surface. Nails in nude mice are deformed, based on alterations of the onychocyte differentiation process. Elemental microanalysis of the(More)
Bombesin (gastrin-releasing peptide 14-27) inhibits gastric function and feeding when microinjected into the nucleus of the solitary tract (NTS)/dorsal motor nucleus of the vagus (DMV) complex. We performed a preembedding immunoelectron microscopic study in rats to describe the bombesin containing nerve terminals and to characterize their postsynaptic(More)
The induction of labor involves a series of complex mechanisms, the control of which is only partially explained in humans. It is accepted today that the maturing of the uterine cervix is independent of the onset of uterine contractions. These two phenomena are regulated by a complex system where prostaglandins play a key role.
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