Learn More
Traditionally, proteins have been viewed as a construct based on elements of secondary structure and their arrangement in three-dimensional space. In a departure from this perspective we show that protein structures can be modelled as network systems that exhibit small-world, single-scale, and to some degree, scale-free properties. The phenomenological(More)
We report the latest release (version 3.0) of the CATH protein domain database (http://www.cathdb.info). There has been a 20% increase in the number of structural domains classified in CATH, up to 86 151 domains. Release 3.0 comprises 1110 fold groups and 2147 homologous superfamilies. To cope with the increases in diverse structural homologues being(More)
BACKGROUND Chitinases are prevalent in life and are found in species including archaea, bacteria, fungi, plants, and animals. They break down chitin, which is the second most abundant carbohydrate in nature after cellulose. Hence, they are important for maintaining a balance between carbon and nitrogen trapped as insoluble chitin in biomass. Chitinases are(More)
This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved(More)
To advance our understanding of the protein folding process, we use stopped-flow far-ultraviolet (far-UV) circular dichroism and quenched-flow hydrogen–deuterium exchange coupled with nuclear magnetic resonance (NMR) spectroscopy to monitor the formation of hydrogen-bonded secondary structure in the C-terminal domain of the Fas-associated death domain(More)
Structural, magnetic, and electronic properties of compounds in the series La2-xSrx CuO4-y for 0.05 </= x </= 1.1, with deltax = 0.025, were studied. Resistance, susceptibility, Meissner, and shielding measurements have revealed superconductivity among several members of the series. For x = 0.15, the transition temperature T(c), measured at the midpoint of(More)
We review the current status of Andreev reflection spectroscopy on the heavy fermions, mostly focusing on the case of CeCoIn(5), a heavy-fermion superconductor with a critical temperature of 2.3 K. This is a well-established technique to investigate superconducting order parameters via measurements of the differential conductance from nanoscale metallic(More)
Backbone 15 N relaxation parameters and 15 N– 1 H N residual dipolar couplings (RDCs) have been measured for a variant of human a-lactalbumin (a-LA) in 4, 6, 8 and 10 M urea. In the a-LA variant, the eight cys-teine residues in the protein have been replaced by alanines (all-Ala a-LA). This protein is a partially folded molten globule at pH 2 and has been(More)
Differential conductance spectra are obtained from nanoscale junctions on the heavy-fermion superconductor CeCoIn5 along three major crystallographic orientations. Consistency and reproducibility of characteristic features among the junctions ensure their spectroscopic nature. All junctions show a similar conductance asymmetry and Andreev reflectionlike(More)
  • 1