Les D. Murray

Learn More
P-site inhibitors are adenosine and adenine nucleotide analogues that inhibit adenylyl cyclase, the effector enzyme that catalyzes the synthesis of cyclic AMP from ATP. Some of these inhibitors may represent physiological regulators of adenylyl cyclase, and the most potent may ultimately serve as useful therapeutic agents. Described here are crystal(More)
Serum samples were collected prior to the correction of dystocia in 45 sheep and from nine sheep following a normal parturition. Serum samples collected from a group of 16 non-pregnant ewes acted as non-pregnant controls. The mean serum haptoglobin concentration was significantly elevated (P less than 0.01) in those dystocia cases where dead lambs were(More)
The Conservation Reserve Program (CRP) is a policy administered by the U.S. Department of Agriculture that reimburses landowners for setting aside land previously used for agricultural production and planting it to perennial vegetation. Since its inception in the 1985 Food Security Act, CRP has reshaped the landscape in agricultural areas across the U.S.(More)
A truncated first cytosolic domain of type V adenylyl cyclase (VC(1)) and a truncated second cytosolic domain of type II adenylyl cyclase (IIC(2)) were used alone and in the readily reversible complex (VC(1).IIC(2)) to evaluate interactions with each other and with reversible and irreversible P-site ligands. Enzyme activity was used to assess formation and(More)
By percussion left displaced abomasum (LDA) was identified in a 7-month pregnant Ayrshire cow which had presented with progressive abdominal distension despite a 5-day history of inappetence. An explorative laparotomy was performed and extensive fibrinous adhesions were identified between the abomasum, diaphragm and left abdominal wall. At the centre of(More)
A vertebral body abscess extending into the epidural space causing spinal cord compression was diagnosed in the cervical spinal cord in four lambs and the thoracic spinal cord in four lambs. The affected lambs were aged between 4 and 10 weeks and clinical signs had been present for 7-21 days before veterinary examination. Treatment with high doses of(More)
  • 1