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  • Yongan Li, Jian Kang, +5 authors Marshall S Horwitz
  • Biology
  • 1999 (First Publication: 2 February 1999)
  • FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3–14.7K) that had been shown to prevent tumor necrosis factorContinue Reading
  • Lisa Placanica, Leonid Tarassishin, +5 authors Yue-Ming Li
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2009 (First Publication: 30 January 2009)
  • γ-Secretase is known to play a pivotal role in the pathogenesis of Alzheimer disease through production of amyloidogenic Aβ42 peptides. Early onset familial Alzheimer disease mutations in presenilinContinue Reading
  • Denis Krausé, Hyeon-sook Suh, +8 authors Sunhee Lee
  • Biology, Medicine
  • The American journal of pathology
  • 2011 (First Publication: 1 September 2011)
  • Tryptophan metabolism by the kynurenine pathway (KP) is important to the pathogenesis of inflammatory, infectious, and degenerative diseases. The 3-hydroxykynurenine (3-HK) branch of the KP isContinue Reading
  • Yu Deng, Leonid Tarassishin, +4 authors Hui Zheng
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2006 (First Publication: 5 April 2006)
  • γ-Secretase processing of the amyloid precursor protein (APP) generates Aβ40 and Aβ42, peptides that constitute the principal components of the β-amyloid plaque pathology of Alzheimer's disease (AD).Continue Reading
  • Leonid Tarassishin, Olivier Loudig, Avital Bauman, Bridget Shafit-Zagardo, Hyeon-sook Suh, Sunhee Lee
  • Medicine, Biology
  • Glia
  • 2011 (First Publication: 1 December 2011)
  • Astrocytes, together with microglia and macrophages, participate in innate inflammatory responses in the CNS. Although inflammatory mediators such as interferons generated by astrocytes may beContinue Reading