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- A Boothroyd, T Hnath-Chisolm, L Hanin, L Kishon-Rabin
- Ear and hearing
- 1988

Recognition of words in conversational sentences of known topic was measured in nine normally hearing subjects by speechreading alone and by speechreading supplemented with auditory presentation of the output of an electroglottograph. Mean word recognition probability rose from 30% to 77% with the addition of the acoustic signal. When this signal was… (More)

- Leonid G Hanin
- Mathematical biosciences
- 2004

The iterated birth and death Markov process is defined as an n-fold iteration of a birth and death Markov process describing kinetics of certain population combined with random killing of individuals in the population at moments tau 1,...,tau n with given survival probabilities s1,...,sn. A long-standing problem of computing the distribution of the number… (More)

- Leonid G Hanin, Anthony Miller, A V Zorin, Andrei Y Yakovlev
- Journal of the National Cancer Institute…
- 2006

This paper presents a biologically motivated model of breast cancer development and detection allowing for arbitrary screening schedules and the effects of clinical covariates recorded at the time of diagnosis on posttreatment survival. Biologically meaningful parameters of the model are estimated by the method of maximum likelihood from the data on age and… (More)

- Leonid Hanin
- Cancers
- 2011

We discuss philosophical, methodological, and biomedical grounds for the traditional paradigm of cancer and some of its critical flaws. We also review some potentially fruitful approaches to understanding cancer and its treatment. This includes the new paradigm of cancer that was developed over the last 15 years by Michael Retsky, Michael Baum, Romano… (More)

- Marco Zaider, Leonid Hanin
- Medical physics
- 2011

Patients undergoing radiation therapy (and their physicians alike) are concerned with the probability of cure (long-term recurrence-free survival, meaning the absence of a detectable or symptomatic tumor). This is not what current practice categorizes as "tumor control (TC);" instead, TC is taken to mean the extinction of clonogenic tumor cells at the end… (More)

- Leonid Hanin, Marco Zaider
- Cancers
- 2011

This article brings mathematical modeling to bear on the reconstruction of the natural history of prostate cancer and assessment of the effects of treatment on metastatic progression. We present a comprehensive, entirely mechanistic mathematical model of cancer progression accounting for primary tumor latency, shedding of metastases, their dormancy and… (More)

- Marco Zaider, Leonid Hanin
- Physics in medicine and biology
- 2007

Within the linear-quadratic model the biologically-effective dose (BED)-taken to represent treatments with an equal tumor control probability (TCP)-is commonly (and plausibly) calculated according to BED(D) = -log[S(D)]/alpha. We ask whether in the presence of cellular proliferation this claim is justified and examine, as a related question, the extent to… (More)

- Leonid Hanin
- Advances in experimental medicine and biology
- 2013

The hypothesis of early metastasis was debated for several decades. Dormant cancer cells and surgery-induced acceleration of metastatic growth were first observed in clinical studies and animal experiments conducted more than a century ago; later, these findings were confirmed in numerous modern studies.In this primarily methodological work, we discuss… (More)

- Leonid Hanin, Marco Zaider
- Physics in medicine and biology
- 2014

We revisit a long-standing problem of optimization of fractionated radiotherapy and solve it in considerable generality under the following three assumptions only: (1) repopulation of clonogenic cancer cells between radiation exposures follows linear birth-and-death Markov process; (2) clonogenic cancer cells do not interact with each other; and (3) the… (More)

- Leonid Hanin, Olga Korosteleva
- Mathematical biosciences
- 2010

A comprehensive mechanistic model of cancer natural history was utilized to obtain an explicit formula for the distribution of volumes of detectable metastases in a given secondary site at any time post-diagnosis. This model provided an excellent fit to the volumes of n=31, 20 and 15 bone metastases observed in three breast cancer patients 8 years, 5.5… (More)