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This article brings mathematical modeling to bear on the reconstruction of the natural history of prostate cancer and assessment of the effects of treatment on metastatic progression. We present a comprehensive, entirely mechanistic mathematical model of cancer progression accounting for primary tumor latency, shedding of metastases, their dormancy and(More)
We discuss philosophical, methodological, and biomedical grounds for the traditional paradigm of cancer and some of its critical flaws. We also review some potentially fruitful approaches to understanding cancer and its treatment. This includes the new paradigm of cancer that was developed over the last 15 years by Michael Retsky, Michael Baum, Romano(More)
the world's scientific community lost one of its most brilliant and innovative members – Dr. Andrei Yakovlev. He was 63, and at the zenith of his intellectual powers. With his uncanny ability to persuade and to ignite interest in his ideas, he challenged and stimulated everyone around him through his keen scientific vision and unparalleled intellectual(More)
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