Leonhardt Bauer

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Achyrocline satureioides (Lam.) DC. inflorescences have been used as remedies in folk medicine for the treatment of a variety of human ailments, particularly those of the gastrointestinal tract. Different extracts of inflorescences have been tested for anti-inflammatory, analgesic, antispasmodic, constipating and sedative activities. The aqueous extracts(More)
Zucker diabetic fatty (ZDF) rats are a standard animal model for the study of type 2 diabetes and for pharmacological characterization of insulin-sensitizing drugs. To analyze the age-dependent development of their metabolic derangements and the associated changes in their responses to treatment with the insulin sensitizer pioglitazone, groups of 7, 10.5,(More)
Starting off with a structure derived from the natural compound multiflorine, a derivatisation program aimed at the discovery and initial characterisation of novel compounds with antidiabetic potential. Design and discovery of the structures was guided by oral bioactivities obtained in oral glucose tolerance tests in mice. 55P0110, one among several new(More)
Murine Atherosclerosis To the Editor: With great interest and curiosity we awaited the publication of the article by Morris et al,1 ever since the presentation of their preliminary data at the ISMRM conference last year.2 Their article answers the question whether or not MRI of plaque macrophages in a widely used murine animal model of atherosclerosis is(More)
Inspired by recent speculation about the potential utility of α2A-antagonism in the treatment of type 2 diabetes, the study examined the contribution of α2-antagonism vs other mechanisms to the antihyperglycaemic activity of the imidazoline (±)-efaroxan. Effects of the racemate and its pure enantiomers on isolated pancreatic islets and beta cells in vitro,(More)