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Using data from eight UK cohorts participating in the Healthy Ageing across the Life Course (HALCyon) research programme, with ages at physical capability assessment ranging from 50 to 90+ years, we harmonised data on objective measures of physical capability (i.e. grip strength, chair rising ability, walking speed, timed get up and go, and standing balance(More)
BACKGROUND Grip strength, walking speed, chair rising and standing balance time are objective measures of physical capability that characterise current health and predict survival in older populations. Socioeconomic position (SEP) in childhood may influence the peak level of physical capability achieved in early adulthood, thereby affecting levels in later(More)
Are maternal vitamin D and E intakes during pregnancy associated with asthma in 10-year-old children? In a longitudinal study of 1924 children born to women recruited during pregnancy, maternal vitamin D intake during pregnancy was assessed by the Food Frequency Questionnaire (FFQ) and vitamin E by FFQ and plasma α-tocopherol; respiratory questionnaires(More)
Differences in general cognitive ability (intelligence) account for approximately half of the variation in any large battery of cognitive tests and are predictive of important life events including health. Genome-wide analyses of common single-nucleotide polymorphisms indicate that they jointly tag between a quarter and a half of the variance in(More)
BACKGROUND Metabolic syndrome has been identified as a condition of childhood relatively recently. The aim in this study was to describe the prevalence of metabolic syndrome in children allowing for differences in metabolic syndrome definitions. METHODS This was a systematic review of the OVID, EMBASE, and CINAHL databases, capturing details of overall(More)
BACKGROUND Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children. OBJECTIVE We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children. DESIGN Subjects were from a birth cohort recruited in(More)
BACKGROUND Asthma is a common condition characterised by wheeze. Many different respiratory sounds are interpreted by parents as "wheeze" in young children. AIM To relate different respiratory sounds reported as wheeze in 2-year-olds to asthma outcomes at age 5 years. METHODS As part of a longitudinal cohort study, parents completed respiratory(More)
RATIONALE We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children. OBJECTIVES To assess whether maternal nutrient intake during pregnancy is associated with asthma-related outcomes in children aged 5 yr. METHODS A longitudinal cohort study of 1,861 children born to women(More)
OBJECTIVE To investigate the infant feeding experiences of women and their significant others from pregnancy until 6 months after birth to establish what would make a difference. DESIGN Qualitative serial interview study. SETTING Two health boards in Scotland. PARTICIPANTS 72 of 541 invited pregnant women volunteered. 220 interviews approximately(More)
OBJECTIVE Reduced dietary selenium intake has been linked to the development of asthma. We have investigated whether childhood wheezing symptoms, and asthma up to the age of 5 years are associated with plasma selenium and erythrocyte glutathione peroxidase (GPx) concentrations in pregnant mothers and neonates. METHODS Two thousand pregnant women were(More)