Leonardo T. Yamamoto

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Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = 5). Morphine (1 nM-1 microM) also(More)
We have previously elucidated the opiate-like action of mitragynine, an active principle isolated from the Thai medicinal plant Mitragyna speciosa. In the present study, effects of the related compound, mitragynine pseudoindoxyl on electrically stimulated contraction in guinea pig ileum and mouse vas deferens, and on its binding affinity in the guinea pig(More)
The effect of an indole-alkaloid mitragynine isolated from the Thai medicinal herb kratom (Mitragyna speciosa) on neurogenic contraction of smooth muscle was studied in guinea-pig vas deferens. Mitragynine inhibited the contraction of the vas deferens produced by electrical transmural stimulation. On the other hand, mitragynine failed to affect the(More)
Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitrugym speciosu), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM 3 PM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 + 0.04 (n = 5). Morphine (1 nM 1 PM) also inhibited the(More)
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