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Alzheimer's disease is a neurodegenerative disorder involving extracellular plaques (amyloid-β) and intracellular tangles of tau protein. Recently, tangle formation has been identified as a major event involved in the neurodegenerative process, due to the conversion of either soluble peptides or oligomers into insoluble filaments. At present, the current(More)
Grain hardness is one of the most important characteristics of wheat quality. Soft endosperm is associated with the presence of two proteins in the wild form, puroindoline a and b. The puroindoline genes and their derived proteins are present in the putative wheat diploid ancestors which are thought to be the donors of the A, B and D genomes in common and(More)
The debate about crystallization processes is still ongoing and nonclassical crystallization mechanisms attract more and more attention. This work indicates that polymer induced liquid precursor (PILP) phases play a role for nonclassical calcium carbonate crystallization and growth processes. Here we report the observation of gel-like precursors for the(More)
The transfer of neutrons onto 24Ne has been measured using a reaccelerated radioactive beam of 24Ne to study the (d,p) reaction in inverse kinematics. The unusual raising of the first 3/2+ level in 25Ne and its significance in terms of the migration of the neutron magic number from N=20 to N=16 is put on a firm footing by confirmation of this state's(More)
We present a method based on atomic force microscopy (AFM) to assess the work of adhesion between the interfaces of gold AFM tips functionalized with three peptides derived from β-sheet breaker LPFFD [CLPFFD-NH2 (i0) and their isomers CDLPFF-NH2 (i1) and CLPDFF-NH2 (i2)], and the beta-amyloid protein (Aβ1-42). β-Amyloid protein was deposited onto a highly(More)
The conformation and charge exposure of peptides attached to colloidal gold nanoparticles (AuNPs) are critical for both the colloidal stability and for the recognition of biological targets in biomedical applications such as diagnostics and therapy. We prepared conjugates of AuNPs and three isomer peptides capable of recognizing toxic aggregates of the(More)
The β feeding probability of (102,104,105,106,107)Tc, 105Mo, and 101Nb nuclei, which are important contributors to the decay heat in nuclear reactors, has been measured using the total absorption technique. We have coupled for the first time a total absorption spectrometer to a Penning trap in order to obtain sources of very high isobaric purity. Our(More)
Gamma decays from excited states up to Jpi=6+ in the N=Z-2 nucleus 54Ni have been identified for the first time. Level energies are compared with those of the isobars 54Co and 54Fe and of the cross-conjugate nuclei of mass A=42. The good but puzzling f7/ cross-conjugate symmetry in mirror and triplet energy differences is analyzed. Shell model calculations(More)
Electrical and mechanical properties of dermatan sulfate (DS) molecules are studied in an aqueous environment as a function of pH. DS molecules linked at various points distributed on the surface of mica previously silanizated along with a suitable functionalized microsphere, attached to the cantilever of an atomic force microscope (AFM), provided suitable(More)
  • Alberto Cornejo, Felipe Aguilar Sandoval, +7 authors Francisco Melo
  • 2017
Alzheimer's disease is a common tauopathy where fibril formation and aggregates are the hallmark of the disease. Efforts targeting amyloid-β plaques have succeeded to remove plaques but failed in clinical trials to improve cognition; thus, the current therapeutic strategy is at preventing tau aggregation. Here, we demonstrated that four phenolic(More)