Leonardo Bartoloni

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BACKGROUND The economic cost of dementia is high and can be predicted by cognitive and neuropsychiatric profiles. The differential costs of the various subtypes of dementia are unknown in Argentina, and this study therefore aimed to compare these costs. METHODS Patients with a diagnosis of dementia of Alzheimer-type (DAT), frontotemporal dementia (FTD)(More)
A very high prevalence of multiple sclerosis (MS) has been reported in some Western European and North American countries. The few surveys of MS epidemiology in South America reveal lower prevalence rates, implying that susceptibility varies between distinct ethnic groups, thus forming an important determinant of the geographic distribution of the disease.(More)
Most of the mutations in the presenilin-1 gene (PS-1) are associated with familial Alzheimer's disease (AD). However, certain examples can be associated with frontotemporal dementia (FTD). We performed a clinical evaluation of individuals belonging to a family with the FTD phenotype, and additional molecular studies and neuropathological assessment of the(More)
The ability to a priori predict the QoS of a service orchestration is of pivotal importance for both the design of service compositions and the definition of their SLAs. QoS prediction is challenging because the results of service invocations is not known a priori. In this paper we present an algorithm to probabilistically predict the QoS of a WS-BPEL(More)
An innovative fabrication procedure has been developed to obtain YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-x</sub> (YBCO) nanobridges from c-axis oriented films. The novelty regards the use of a thin titanium mask used in the patterning process. The use of the Ti makes simpler the fabrication procedure guaranteeing high quality devices, as demonstrated by(More)
Yerba mate tea is a very common beverage in some countries of South America. We conducted a case-control study on an individual basis using hospital records to investigate the association between Parkinson's disease (PD) and yerba mate intake. A case was defined as an age of ≥ 40 years with ≥ 1 year of PD. Each case was individually matched by two controls.(More)
Phototest is a simple, easy and very brief test with theoretical advantages over available dementia screening tests in Spain. The objective of this study was to estimate the diagnostic accuracy of the Phototest for cognitive impairment and dementia and to compare it with that of the MMSE and the Clock Drawing Test (CDT) in an Argentine population. A phase(More)
We report a 77-year-old man, presenting with progressive aphasia as an initial symptom, who developed severe dementia over the course of 20 months. Frontal cortex PrPSc western blot was type 2 and codon 129 was MM; brain neuropathology showed cortical vacuoles with perivacuolar PrP immunostaining characteristic of MM2C. Cerebellum showed focal coarse,(More)