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- Keertan Dheda, Virginia Davids, +16 authors Alimuddin M. Zumla
- PloS one
- 2010
BACKGROUND
The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay… (More)
- Claudio Pagano, Giorgio Soardo, +6 authors Roberto Vettor
- European journal of endocrinology
- 2005
OBJECTIVES
Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and is frequently associated with obesity and metabolic syndrome. The recently discovered hormone… (More)
- Keertan Dheda, Richard N van Zyl-Smit, +13 authors Allimudin Zumla
- The European respiratory journal
- 2009
The clinical utility of antigen-specific interferon (IFN)-gamma release assays (IGRAs) using pleural mononuclear cells, for the diagnosis of tuberculosis (TB), requires clarification. We compared the… (More)
- Cristiana Catena, Gianluca Colussi, +4 authors Leonardo A Sechi
- Archives of internal medicine
- 2008
BACKGROUND
Experimental and human studies demonstrate that long-term exposure to elevated aldosterone levels results in cardiac and vascular damage.
METHODS
We investigated long-term cardiovascular… (More)
- Leonardo A Sechi, Marileda Novello, +4 authors Cristiana Catena
- JAMA
- 2006
CONTEXT
Experimental animal studies indicate that exposure to increased aldosterone levels might result in renal damage, but the clinical evidence supporting this role of aldosterone is preliminary.… (More)
- Cristiana Catena, Gilberta Giacchetti, Marileda Novello, Gianluca Colussi, Alessandro Cavarape, Leonardo A Sechi
- American journal of hypertension
- 2003
BACKGROUND
Feeding a high-fructose diet induces hypertension and insulin-resistance in Sprague-Dawley rats.
METHODS
To investigate whether insulin receptors contribute to abnormal glucose… (More)
- Leonardo A Sechi, Cora A Griffin, Eileen F. Grady, Judith E. Kalinyak, Morris Schambelan
- Circulation research
- 1992
Angiotensin II exerts positive inotropic and chronotropic effects on the mammalian heart by binding to specific membrane receptors. Recently, two subtypes of angiotensin II receptors (AT1 and AT2)… (More)
- Leonardo A Sechi, Alessandra Melis, Rinaldo Tedde
- Metabolism: clinical and experimental
- 1992
Several studies have demonstrated that patients with hypertension have greater plasma insulin levels than normotensive subjects. The aim of the present study was to clarify if hyperinsulinemia in… (More)
- Eileen F. Grady, Leonardo A Sechi, Cora A Griffin, Morris Schambelan, Judith E. Kalinyak
- The Journal of clinical investigation
- 1991
Angiotensin II is known primarily for its effects on blood pressure and electrolyte homeostasis, but recent studies suggest that angiotensin II may play a role in the regulation of cellular growth.… (More)
- Gilberta Giacchetti, Leonardo A Sechi, Silvia Rilli, R. M. Carey
- Trends in Endocrinology & Metabolism
- 2005
In diabetes mellitus (DM), the circulating renin-angiotensin system (RAS) is suppressed, but the renal tissue RAS is activated. Hyperglycemia increases tissue angiotensin II (Ang II), which induces… (More)