Leona Snezhkova

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The cyclopeptide antibiotic gramicidin S taken at a concentration of 100--200 mkg/mg membrane protein rapidly increases the permeability of M. lysodeikticus protoplast membranes for substrates of respiratory chain and exogenous cytochromes c. Prolonged incubation of gramicidin S with protoplasts results in their lysis which is more fast at low temperatures.(More)
Toxic agents, derived from bee or hornet venoms and from fungi - melittin, mastoparan, and alamethicin are able to permeabilize biological membranes. We studied the initial steps of pore formation by these peptides in rat liver mitochondria preparations (RLM) generating transmembrane potential (ΔΨ). RLM has been used as a potassium transmembrane current(More)
1. A new method has been proposed for studying the conformational states of peptides in solutions which is based on a consideration of the ESR spectra of their spin-labeled derivatives. 2. The synthesis of derivatives of gramicidin S containing one and two iminoxyl radicals in the2Orn and7Orn side chains has been effected. 3. On the basis of an analysis of(More)
Tertiapin, a neurotoxin from the honey bee venom, interacts specifically with calmodulin in the presence of Ca2+. The nature of this interaction was studied using calmodulin-cAMP phosphodiesterase system. Tertiapin does not affect the unstimulated basal activity of phosphodiesterase. However, it totally inhibits the enzyme-activating capacity of calmodulin.(More)
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