Leon Rosenstein

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3085 Background: The RAS/RAF/MEK and PI3K/AKT pathways are activated in many human cancers. GSK212 is a potent and selective allosteric inhibitor of MEK1/2 and GSK795 is a potent ATP-competitive inhibitor of all three isoforms of AKT. The objectives of this study were to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK212 dosed in(More)
A Mildly Polemical Preface It needs finally to be said, in paraphrase and in extension of Hegel, that art theory on the side of its highest possibilities is a thing of the past. How did this come about? How did art theory come to its demise? Things die off in various ways: they wear out, they dissipate into triviality, they self-destruct, they no longer(More)
Placental transfer and fetal toxicity of pesticides have been documented in normotensive rats but no reports appear in the literature regarding the susceptibility of spontaneously hypertensive (SHR) perinates to pesticide challenge. This report describes the effects of prolonged parathion exposure to perinatal rats born to hypertensive dams. Ninety day old,(More)
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