Leon Manning

  • Citations Per Year
Learn More
UNLABELLED BACKGROUND Total contact casting is regarded as the gold standard treatment for plantar foot ulcers. Load transfer from the plantar surface of the foot to the walls of the total contact cast has previously been assessed indirectly. The aim of this proof of concept study was to determine the feasibility of a new method to directly measure the(More)
A multiple-dose bioequivalence study with six healthy human volunteers was conducted. The bioavailability of an experimental controlled release tablet containing pseudoephedrine was compared with a marketed controlled release pseudoephedrine capsule in a three-way crossover study. Plasma samples, collected serially after oral drug administration, were(More)
Background The success of the total contact cast (TCC) is attributed to its ability to reduce pressure at the ulcer site coupled with forced patient compliance. The mechanism of offloading plantar pressure with a TCC is purported to be by redistributing weight-bearing force across the entire plantar surface of the foot and increasing the plantar surface(More)
Background The mechanism of offloading plantar pressure with a TCC is by redistributing weight-bearing load across the entire plantar surface of the foot and increasing the plantar surface contact area [1]. An additional mechanism is by transfer of load to the cast walls however these studies relied on indirect methods [2-4]. No previous research has(More)
  • 1