Leon M Brownrigg

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We examined whether macrophages from men and women with Type 2 diabetes mellitus (T2DM) exhibited differences in expression of key genes involved in fatty acid metabolism and in fatty acid composition compared with macrophages from non-diabetic controls. Peripheral blood monocytes from subjects with T2DM (n=9) and non-diabetic controls (n=10) were(More)
We sought to compare the effects of the thiazolidinedione ciglitazone with the endogenous fatty acid PPARgamma agonists 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE), in U937 monocytic cells. Ciglitazone and 9-HODE inhibited cell proliferation and all three agonists increased cellular content of C18:0 fatty acids. Ciglitazone and 13-HODE resulted(More)
Dear Sir, Lipoprotein lipase (LPL) is a homodimeric lipolytic enzyme that hydrolyses triglycerides from triglyceride-rich lipoprotein particles at the luminal wall of capillaries, primarily in muscle and adipose tissue, to produce non-esterified fatty acids for energy or storage by adjacent tissues [1]. It is also involved in lipoprotein clearance through(More)
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