Leon Liebenberg

Learn More
BACKGROUND Moderate alcohol consumption is associated with a lower risk for coronary heart disease (CHD). A suitably integrated view of the CHD pathogenesis pathway will help to elucidate how moderate alcohol consumption could reduce CHD risk. METHODS A comprehensive literature review was conducted focusing on the pathogenesis of CHD. Biomarker data were(More)
BACKGROUND Diet has a significant relationship with the risk of coronary heart disease (CHD). Traditionally the effect of diet on CHD was measured with the biomarker for low-density lipoprotein (LDL) cholesterol. However, LDL is not the only or even the most important biomarker for CHD risk. A suitably integrated view of the mechanism by which diet(More)
Due to their high proliferative requirements, tumorigenic cells possess altered metabolic systems whereby cells utilize higher quantities of glutamine and glucose. These altered metabolic requirements make it of interest to investigate the effects of physiological non-tumorigenic concentrations of glucose and glutamine on tumorigenic cells since deprivation(More)
BACKGROUND Depression is known to increase the risk for coronary heart disease (CHD) likely through various pathogenetic actions. Understanding the links between depression and CHD and the effects of mediating these links may prove beneficial in CHD prevention. METHODS An integrated model of CHD was used to elucidate pathogenetic pathways of importance(More)
We respond to a recent paper by Daphu et al. [1]. The authors inter alia report that most metastases studies have focussed on a characterization of the tumor cell (''seed'') and neglect potential contribution from the microenviron-ment of the target organ (''soil''). We agree and thus focus on the energy microenvironment in this letter. Brain metastasis has(More)
  • 1