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We show that the nuclear architecture of rod photoreceptor cells differs fundamentally in nocturnal and diurnal mammals. The rods of diurnal retinas possess the conventional architecture found in nearly all eukaryotic cells, with most heterochromatin situated at the nuclear periphery and euchromatin residing toward the nuclear interior. The rods of(More)
1. Receptive field centre sizes of brisk-sustained (X) and brisk-transient (Y) ganglion cells of the cat retina were assessed by three different methods: small spot mapping, area threshold method and spatial resolution. 2. Centre sizes of brisk-sustained (X) cells increased from 20' in the central area to about 70' at an eccentricity of 4.5 mm, centre sizes(More)
Rabbit retinal ganglion cells were retrogradely labeled following injection of rhodamine-labeled microspheres into the medial terminal nucleus. The small fraction of rhodamine-labeled neurons reached their peak concentration within the visual streak and then decreased with increasing eccentricity until none were encountered in the far periphery. The same(More)
Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in different tissues and species, including mice with mutations in the lamin B receptor (Lbr) and lamin A (Lmna) genes that encode nuclear envelope (NE) proteins. We identified LBR-(More)
The transmitters acetylcholine and gamma-aminobutyrate (GABA) play critical roles in the formation of receptive-field properties of retinal ganglion cells. In rabbit retina, cholinergic amacrine and displaced amacrine cells were identified by immunohistochemical staining for the enzyme choline acetyltransferase and by their avid accumulation of the(More)
Of the 3 anatomically defined classes of ganglion cell in adult cat retina, the alpha and beta cells are the most well documented, thus providing a basis of comparison for developing ganglion cells. Alpha and beta ganglion cells in cat retinae at various ages from birth (P0) to adult were intracellularly injected with Lucifer yellow. At all ages, both cell(More)
In the rabbit retina a distinctive morphological class of large ganglion cells was demonstrated by a combination of intracellular staining with Lucifer Yellow and the quantification of reduced silver-stained preparations. The class is called alpha because of the qualitative and quantitative resemblance to the alpha cells of the cat's retina. Rabbit alpha(More)
  • L Peichl
  • 1989
In the rat retina a distinctive class of large ganglion cell was demonstrated by intracellular staining with Lucifer Yellow and with reduced silver staining. They are referred to as alpha cells because they resemble the alpha cells of other mammalian retinae. A second class, called delta cells, is also described. Both classes belong to the type I group(More)
Retinal horizontal cells of four rodent species, rat, mouse, gerbil, and guinea pig were examined to determine whether they conform to the basic pattern of two horizontal cell types found in other mammalian orders. Intracellular injections of Lucifer-Yellow were made to reveal the morphologies of individual cells. Immunocytochemistry with antisera against(More)
Neurofibrillar staining methods were found to stain all alpha cells of the cat retina completely, that is the perikaryon, the axon and the dendritic branches. The dendrites of the alpha cells in vertical sections were found to be unistratified and to occupy two narrow strata in the outer half of the inner plexiform layer. This difference in branching level(More)