Leo Njock Ayuk

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BACKGROUND Alcohol consumption is prevalent amongst HIV positive population. Importantly, chronic alcohol use is reported to exacerbate HIV pathogenesis. Although alcohol is known to increase oxidative stress, especially in the liver, there is no clinical evidence that alcohol increases oxidative stress in HIV positive patients. The mechanism by which(More)
Mild-to-moderate tobacco smoking is highly prevalent in HIV-infected individuals, and is known to exacerbate HIV pathogenesis. The objective of this study was to determine the specific effects of mild-to-moderate smoking on viral load, cytokine production, and oxidative stress and cytochrome P450 (CYP) pathways in HIV-infected individuals who have not yet(More)
Human immunodeficiency virus (HIV)-associated tuberculosis is a major public health threat. We evaluated the safety and immunogenicity of the candidate tuberculosis vaccine M72/AS01 in HIV-positive and HIV-negative Indian adults.Randomized, controlled observer-blind trial (NCT01262976).We assigned 240 adults (1:1:1) to antiretroviral therapy (ART)-stable,(More)
The ParalensTM (PL) microscope attachment converts a light microscope into an epi-fluorescence microscope. We compared the PL to standard fluorescence microscopy for detection of Mycobacteria in clinical and spiked samples. Overall agreement between the two systems was 100%. Quantitative and qualitative performance was comparable. The PL is an acceptable(More)
BACKGROUND Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where Plasmodium species are indigenous,(More)
There is an urgent need for affordable CD4 enumeration to monitor HIV disease. CD4 enumeration is out of reach in resource-limited regions due to the time and temperature restrictions, technical sophistication, and cost of reagents, in particular monoclonal antibodies to measure CD4 on blood cells, the only currently acceptable method. A commonly used(More)
OBJECTIVE To determine the resistance of Mycobacterium tuberculosis to first- and second-line agents in adult pulmonary tuberculosis (TB) patients in Cameroon using a novel phenotypic assay. SETTING Samples were collected from TB patients at Bamenda Hospital in Bamenda, Cameroon. DESIGN Samples were collected consecutively from adult pulmonary TB(More)
Introduction The determination of CD4 counts in patients with HIV/AIDS is of paramount importance clinically to determine when to initiate anti-retroviral therapy (ART). ART slows disease progression, reduces viral load and significantly reduces HIV transmission. Currently, the only methods for obtaining CD4 counts use flow cytometry technology.(More)
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