Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000.
- Leo M. H. Leung, C. Tomassi, B. Linclau
- ChemistryOrganic Letters
- 18 September 2008
The synthesis of 4-deoxy-4,4-difluoro-KRN7000 starting from phytosphingosine reveals a bias toward Th1 cytokine induction upon Natural Killer T cell activation.
The Synthesis and in vivo Evaluation of 2′,2′‐Difluoro KRN7000
- Leo M. H. Leung, C. Tomassi, B. Linclau
- Biology, ChemistryChemMedChem
- 16 March 2009
In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d‐dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
A convenient AIBN-initiated radical addition of ethyl iododifluoroacetate to alkenes
- Leo M. H. Leung, B. Linclau
- Chemistry
- 1 October 2008
A linchpin carbacyclization approach for the synthesis of carbanucleosides.
- Leo M. H. Leung, V. Gibson, B. Linclau
- ChemistryJournal of Organic Chemistry
- 5 December 2008
The key step is a tandem linchpin cyclization process to give access to substituted carbafuranose derivatives having the correct relative stereochemistry for subsequent nucleobase introduction with inversion of configuration at C1.
Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane
- B. Linclau, Leo M. H. Leung, J. Nonnenmacher, G. Tizzard
- ChemistryBeilstein Journal of Organic Chemistry
- 8 June 2010
A large-scale synthesis of meso-2,3-difluoro-1,4-butanediol in 5 steps from (Z)-but-2-enediol is described, which reveals an anti conformation of the vicinal difluoride moiety.
Improved synthesis of enantiopure pseudo-C2-symmetric 1,4-bis-epoxide building blocks from arabitol
- Leo M. H. Leung, V. Gibson, B. Linclau
- Chemistry
- 18 July 2005
Improving the stability of 11C–labeled L-methionine with ascorbate
- Michael Woods, Leo M. H. Leung, Kuo‐Shyan Lin
- MedicineEJNMMI Radiopharmacy and Chemistry
- 4 October 2017
To minimize oxidation, ascorbate was added to the HPLC eluant, and the resulting HPLC-purified 11C–MET was stable in the final formulation solution without noticeable degradation for up to 1 h after the end of synthesis.
A stereoselective cyclization to carbafuranose derivatives starting from 1,4-bis-epoxides.
- Leo M. H. Leung, A. Boydell, V. Gibson, M. Light, B. Linclau
- ChemistryOrganic Letters
- 15 October 2005
[reactions: see text] A concise synthesis of highly functionalized cyclopentane derivatives via a Brook rearrangement mediated stereoselective linchpin cyclization reaction involving…
An Enantioselective Synthesis of Carbafuranose Sugars Based on a Linchpin Carbacyclization Approach.
- Leo M. H. Leung, M. Light, V. Gibson, B. Linclau
- Chemistry
- 6 October 2009
The Synthesis and in vivo Evaluation of 2 ’ , 2 ’-Difluoro KRN 7000
- Leo M. H. Leung, C. Tomassi, B. Linclau
- Chemistry, Biology
- 2009
(a-linked) galactosylceramide, and it was shown that its action as an antigen arises by binding to a CD1d protein, followed by recognition of the complex by the semi-invariant T cell receptor (TCR)…
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