Lenny van Bon

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A rare polymorphism in Toll Like Receptor 2 is associated with systemic sclerosis phenotype and increases production of inflammatory mediators Jasper CA Broen, Lara Bossini-Castillo, Lenny van Bon, Madelon C Vonk, Hanneke Knaapen, Lorenzo Beretta, Blanca Rueda, Roger Hesselstrand, Ariane Herrick, Jane Worthington, Nicholas Hunzelmann, Christopher Denton,(More)
Background: Regulatory T cells (Tregs) are essential in the control of tolerance. Evidence implicates Tregs in human autoimmune conditions. Here we investigated their role in systemic sclerosis (SSc). Methods/Principal Findings: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 20) or diffuse cutaneous SSc (dcSSc, n = 48). Further(More)
Antigen-presenting cells (APCs) play an important role in the development of autoimmune diseases. These cells recognize pathogen associated molecular patterns but also endogenously produced ligands through toll-like receptors (TLRs). Aberrant activation of these receptors and the following intracellular signaling pathways can induce the deleterious(More)
Background: Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc. Methodology and Principal Findings: Patients were subdivided as having limited cutaneous SSc (lcSSc, n = 12) or diffuse cutaneous SSc (dcSSc, n = 24). A further(More)
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