Lennie Epshtein

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The monoamine oxidase (MAO) from the liver of Comandor squid inhabiting at depth of 800 m transformed histamine along with specific substrates (tyramine, serotonin, benzylamine). MAO from the squid nervous ganglia as well as from mouse liver and brain was inactive towards histamine. Under normal atmospheric pressure the activity of the enzyme prepared from(More)
It is the first time when the substrate specificity is considered as a complex phenomenon, taking into account an influence of substrate structure on the rate of enzymatic hydrolysis and interaction of cholinesterases with reversible and irreversible inhibitors. Kinetic parameters of hydrolysis of 18 esters, including choline, ammonium and indophenol(More)
Authors had received and investigated on experiment milk medical and prophylactic products (milk and kefir) with addition peptide, obtained from nervous tissue of squids. It has been established that addition of gangliin to the milk and kefir causes stimulation cellular and humoral factors of immunity answer at laboratory animals. Medical and prophylactic(More)
The optimal conditions of enzymatic hydrolysis of proteins different composition and structure (protamin, casein, haemoglobin, fibrin, collagen) were established by using proteolytic enzymatic preparations with different specificity (pancreatin, pilrin, hepatopancreatin). The degree of hydrolysis, molecular and amino acid compositions of proteins were(More)
Conditions for transformation of tissue adenosine-5'-monophosphate (AMP) into inosine-5'-monophosphate (IMP) with the aid of endogenic AMP-aminohydrolase are developed resting on the studied properties of AMP-aminohydrolase (EC 3.5.4.6) from saltwater fish muscles (one of the enzymes participating in the nucleotide metabolism). Sorption of the nucleotide is(More)
The data on the effect of a peptide from the squid optic ganglia named gangliin on some parameters of animal natural resistance are presented. It was shown that the prophylactic use of the peptide in mice 24 hours before their contamination with the lethal dose of E. coli protected 40 to 60 per cent of the animals from death. Gangliin accelerated(More)
Conformational properties of a series of polymethylenebis (trimethylammonium) derivatives [formula: see text] (n = 4-10), cholinesterase reversible inhibitors, were studied by molecular mechanics method. Conformation-activity relationships between these inhibitors and human erythrocyte acetylcholinesterase, horse plasma butyrylcholinesterase,(More)