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The behavioral sensitization produced by repeated treatment with amphetamine may represent neural adaptations underlying some of the features of psychosis and addiction in humans. Under some circumstances, learning contextual cues can gain powerful control over the ability of the sensitized neural substrate to influence behavior. Here, we investigated the(More)
The effects of developmental lead exposure on the emotional reactivity, contextual fear conditioning and neurogenesis in the dentate gyrus of 60-80 days-old rats were studied. Wistar rat pups were exposed to 0.2% lead acetate via their dams' drinking water from postnatal day (PND) 1 to PND 21 and directly via drinking water from weaning until PND 30. At PND(More)
The behavioral sensitization produced by repeated amphetamine treatment may represent the neural adaptations underlying some of the features of psychosis and addiction in humans. Chromatin modification (specifically histone hyperacetylation) was recently recognized as an important regulator of psychostimulant-induced plasticity. We have investigated the(More)
Although lead is widely known as a potent neurotoxin, the effect of lead exposure on the expression of the polysialic acid linked neural cell adhesion molecule (PSA-NCAM) remains unclear. We exposed Wistar rat pups to 0.2% lead acetate from postnatal day (PND) 1 to PND 30. This exposure protocol resulted in pup blood lead levels, which increased to(More)
BACKGROUND The amount of blood that can be safely drawn from a preterm neonate for scientific purposes is poorly established. OBJECTIVES To provide scientific evidence on the amount of blood that can be drawn from very low birth weight (VLBW) neonates for study purposes. METHODS We performed a post-hoc analysis of a pharmacokinetic (PK) study of(More)
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