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  • Lennart Mucke, Eliezer Masliah, +7 authors Lisa McConlogue
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2000 (First Publication: 1 June 2000)
  • Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and dementia remains controversial. In contrast, there is a good correlationExpand
  • Jorge J Palop, Jeannie Chin, +10 authors Lennart Mucke
  • Biology, Medicine
  • Neuron
  • 2007 (First Publication: 1 September 2007)
  • Neural network dysfunction may play an important role in Alzheimer's disease (AD). Neuronal circuits vulnerable to AD are also affected in human amyloid precursor protein (hAPP) transgenic mice. hAPPExpand
  • Toby G. Bush, Narman Puvanachandra, +6 authors Michael V Sofroniew
  • Biology, Medicine
  • Neuron
  • 1999 (First Publication: 1 June 1999)
  • Reactive astrocytes adjacent to a forebrain stab injury were selectively ablated in adult mice expressing HSV-TK from the Gfap promoter by treatment with ganciclovir. Injured tissue that was depletedExpand