Lenko Grigorov

Learn More
The normal tissue complication probability (NTCP) is a predictor of radiobiological effect for organs at risk (OAR). The calculation of the NTCP is based on the dose-volume-histogram (DVH) which is generated by the treatment planning system after calculation of the 3D dose distribution. Including the NTCP in the objective function for intensity modulated(More)
This study was undertaken to investigate the dynamics of glomerular filtration and serum beta 2-microglobulin in patients with confirmed autosomal dominant polycystic kidney disease (ADPKD) without chronic renal failure (CRF). Twenty five patients (11 women and 14 men, age range 15 to 56 years) with echographically and computer-tomographically proven ADPKD(More)
We present a mechanism for initiating mediated conversations through eye contact. An eyePHONE is a physical proxy of a remote individual that senses and conveys attention using an eye tracking device and a pair of actuated eyeballs. Users may initiate calls by jointly looking at each other's eyePHONE. We discuss how this allows participants to implement(More)
A class of time-varying discrete-event systems, named dynamic discrete-event systems, is defined. The goal of this paper is to provide a method which is modular and can be applied in real solutions for the optimization of the online control of such systems. First, a simple control algorithm is presented, followed by illustrative examples of different issues(More)
Transcriptional regulation and binding interactions between soluble nucleoproteins and the distal regulatory element (DRE) of the rat alpha 1-acid glycoprotein (alpha 1-AGP) gene were examined in the liver of rats during the acute-phase response. Our results show that the elevation of the alpha1-AGP gene transcription activity in acute phase liver relies(More)
A new methodology for the design of DES control is proposed which allows for the creation of conceptual designs by using encapsulated low-level elements. The approach can be used within the standard framework of modular supervisory control. The notion of DES templates is introduced, where both DES modules and specifications are represented as high-level(More)
Irradiation flavour in apple juice and concentrate which is mainly attributable, according to our previous studies, to tetrahydrofuran (THF) that may be quantitatively determined by means of the so-called mercury acetate method. This is based on the fact that the amount of a 4% solution of mercury acetate needed for removing the THF odour is proportional to(More)