BACKGROUND Abnormal postprandial elevation of plasma glucose and lipids plays an important role in the pathogenesis of diabetes and strongly predicts cardiovascular mortality. In patients suffering from type 2 diabetes (T2D) postprandial state is associated with oxidative stress, cardiovascular risk and, probably, with impairment of both secretion and the… (More)
AIMS/HYPOTHESIS The aim of the study was to compare the effect of six (A6 regimen) vs two meals a day, breakfast and lunch (B2 regimen), on body weight, hepatic fat content (HFC), insulin resistance and beta cell function. METHODS In a randomised, open, crossover, single-centre study (conducted in Prague, Czech Republic), we assigned 54 patients with type… (More)
BACKGROUND The intake of meat, particularly processed meat, is a dietary risk factor for diabetes. Meat intake impairs insulin sensitivity and leads to increased oxidative stress. However, its effect on postprandial gastrointestinal hormone (GIH) secretion is unclear. We aimed to investigate the acute effects of two standardized isocaloric meals: a… (More)
BACKGROUND Appetite and gastrointestinal hormones (GIHs) participate in energy homeostasis, feeding behavior and regulation of body weight. We demonstrated previously the superior effect of a hypocaloric diet regimen with lower meal frequency (B2) on body weight, hepatic fat content, insulin sensitivity and feelings of hunger compared to the same diet… (More)
Unfortunately the values for Δ HFC in the Abstract and main text and the values on the y-axis of the graph in Fig. 2b were presented as fractions rather than percentages and were therefore 100 times lower than they should have been. The correct values for Δ HFC were −3. A corrected version of the graph is shown here.