Lene Tolstrup Sørensen

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We generated mitochondrial late-onset neurodegeneration (MILON) mice with postnatal disruption of oxidative phosphorylation in forebrain neurons. They develop normally and display no overt behavioral disturbances or histological changes during the first 5 months of life. The MILON mice display reduced levels of mitochondrial DNA and mitochondrial RNA from 2(More)
Heteroplasmic mitochondrial DNA (mtDNA) mutations (mutations present only in a subset of cellular mtDNA copies) arise de novo during the normal ageing process or may be maternally inherited in pedigrees with mitochondrial disease syndromes. A pathogenic mtDNA mutation causes respiratory chain deficiency only if the fraction of mutated mtDNA exceeds a(More)
1 Abstract—When it comes to discussing the future of electronic communication, social networking is the buzzword. The Internet has become a platform where new social networks emerge and the Internet it itself support the more traditional computer supported communication. The way users build and verifies different online networks for communities of people(More)
OBJECTIVE The scope of this article is to describe the background for and content of an adherence counselling programme with a specific focus on an individualised, multi-dimensional adherence model for patients with a potential adherence problem (a so-called 'individualised systems model'). METHODS An intervention programme based on WHO's systems model(More)
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