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OBJECTIVE Gestational weight gain (GWG) is associated with childhood obesity. We analyzed whether this effect persists into adulthood and is mediated by effects in childhood. DESIGN The design of the study a prospective birth cohort study established in 1959-1961. SUBJECTS The subjects were offspring (n = 4234 of whom 2485 had information from the last(More)
Animal and epidemiologic studies indicate that early nutrition has lasting effects on metabolism and cardiovascular disease risk. In adults, (n-3) long-chain PUFA (LCPUFA) from fish oils improve blood pressure, the lipid profile, and possibly cardiovascular disease mortality. This randomized trial is the first to investigate the effects of fish oil on blood(More)
BACKGROUND Prenatal life exposures, potentially manifested as altered birth size, may influence the later risk of major chronic diseases through direct biologic effects on disease processes, but also by modifying adult behaviors such as physical activity that may influence later disease risk. METHODS/PRINCIPAL FINDINGS We investigated the association(More)
OBJECTIVE To assess whether changes in the birth weight distribution or changes in the association of birth weight with the later risk of childhood overweight have contributed to the development of the obesity epidemic. RESEARCH METHODS AND PROCEDURES A Danish population-based cohort study of 124,615 girls and 128,346 boys (ages 6 to 13 years), born(More)
There is an intense interest in the effects of breast-feeding on the offspring and in understanding the mechanisms behind these effects. More than 50 papers are published monthly on topics such as the influence of breast-feeding on aspects of growth, immune-related effects, mental development, and noncommunicable diseases. Most breast-feeding data are(More)
PURPOSE OF REVIEW This review discusses the long-term health effects of breast feeding, based on the most relevant publications from the second half of 2004 and 2005. RECENT FINDINGS The positive effect of breast feeding on later cognitive function continues to be the most consistent and important effect. Also, breast feeding is likely to protect against(More)
The authors investigated the shape, sex- and age-dependency, and possible confounding of the association between birth weight and systolic blood pressure (SBP) in 197,954 adults from 20 Nordic cohorts (birth years 1910-1987), one of which included 166,249 Swedish male conscripts. Random-effects meta-regression analyses were performed on estimates obtained(More)
OBJECTIVE To describe the association between duration of exclusive breast-feeding (EBF), weight gain in infancy and childhood BMI in two populations with a long duration of EBF. DESIGN Cohort study with follow-up in childhood. Breast-feeding status was reported monthly during infancy. Weight and length were measured at birth, 2, 6 and 12 months of age,(More)
BACKGROUND High infancy weight gain is associated with increased body mass index (BMI) and insulin resistance (IR) in later life, but the association with later body composition has not been well explored. Appetite regulatory hormones may be programmed in early life, but data to support this are lacking. OBJECTIVE We investigated the effect of weight gain(More)
OBJECTIVE To explore whether birth weight (BW) has been increasing in Denmark at the same level as in other countries and whether this increase is paralleled by an increase in birth length (BL) or whether body proportionality, expressed as ponderal index (PI), has changed. RESEARCH METHODS AND PROCEDURES This study used data analysis of information from(More)