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The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date. Here we show that JAM-C(-/-) mice backcrossed onto the C57BL/6 genetic background developed a severe hydrocephalus.(More)
How regulatory T cells (T reg cell) control lymphocyte homeostasis is not fully understood. Here we identify two T reg cell populations with differing degrees of self-reactivity and distinct regulatory functions. Triple hi (GITR hi PD-1 hi CD25 hi) T reg cell are highly self-reactive and control lympho-proliferation in peripheral lymph nodes. Triple lo(More)
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