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Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation.
- C. Reinhardt, Marie-Luise von Bruehl, +11 authors B. Engelmann
- Medicine, Chemistry
- The Journal of clinical investigation
- 3 March 2008
The activation of initiator protein tissue factor (TF) is likely to be a crucial step in the blood coagulation process, which leads to fibrin formation. The stimuli responsible for inducing TF… Expand
Radiation-induced motility alterations in medulloblastoma cells
Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying… Expand
Effect of chronic treatment with acetylsalicylic acid and clopidogrel on atheroprogression and atherothrombosis in ApoE-deficient mice in vivo.
Acetylsalicylic acid (ASA) and the thienopyridine clopidogrel are established anti-platelet drugs that significantly reduce secondary cardiovascular events in patients with manifest atherosclerosis.… Expand
The Relative Biological Effectiveness for Carbon and Oxygen Ion Beams Using the Raster-Scanning Technique in Hepatocellular Carcinoma Cell Lines
Background Aim of this study was to evaluate the relative biological effectiveness (RBE) of carbon (12C) and oxygen ion (16O)-irradiation applied in the raster-scanning technique at the Heidelberg… Expand
In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines
- R. E. El Shafie, D. Habermehl, +7 authors S. Combs
- Medicine, Biology
- Journal of radiation research
- 1 July 2013
Background: Pancreatic cancer is the fourth leading cause of cancer deaths, being responsible for 6% of all cancer-related deaths. Conventional radiotherapy with or without additional chemotherapy… Expand
Integrin-based meningioma cell migration is promoted by photon but not by carbon-ion irradiation
- F. Simon, Jan-Oliver Dittmar, +6 authors S. Rieken
- Strahlentherapie und Onkologie
- 1 April 2015
PurposeSublethal doses of photon irradiation (IR) are suspected to increase tumor cell migration and support locoregional recurrence of disease, which has already been shown in other cell lines. This… Expand
Low-dose photon irradiation induces invasiveness through the SDF-1α/CXCR4 pathway in malignant mesothelioma cells.
BACKGROUND Low-dose photon irradiation has repeatedly been suspected to increase a risk of promoting local recurrence of disease or even systemic dissemination. The purpose of this study was to… Expand
In vitro evaluation of carbon and oxygen ion irradiation in hepatocellular carcinoma cell lines
Low-dose photon irradiation induces invasiveness through the SDF-1α/CXCR4 pathway in malignant mesothelioma cells
Background Low-dose photon irradiation has repeatedly been suspected to increase a risk of promoting local recurrence of disease or even systemic dissemination. The purpose of this study was to… Expand