Lelia van Bürck

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Heterozygous male Munich Ins2 C95S mutant mice, a model for permanent neonatal diabetes mellitus, demonstrate a progressive diabetic phenotype with severe loss of functional beta cell mass. The aim of this study was to investigate the influence of early insulin treatment on glucose homeostasis and beta cell destruction in male Munich Ins2 C95S mutants. One(More)
27 Several mutant mouse models for human diseases such as diabetes mellitus have been 28 generated in the large-scale Munich ENU (N-ethyl-N-nitrosourea) mouse mutagenesis project. 29 The aim of this study was to identify the causal mutation of one of these strains and to 30 characterize the resulting diabetic phenotype. Mutants exhibit a T to G transversion(More)
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