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Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.
The mechanisms that underlie and dictate the different biological outcomes of E2F-1 activity have yet to be elucidated. We describe the residue-specific methylation of E2F-1 by the asymmetricExpand
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Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.
Ribosome biogenesis is a highly complex process requiring many assisting factors. Studies in yeast have yielded comprehensive knowledge of the cellular machinery involved in this process. However,Expand
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Type II Inhibitors Targeting CDK2.
Kinases can switch between active and inactive conformations of the ATP/Mg(2+) binding motif DFG, which has been explored for the development of type I or type II inhibitors. However, factorsExpand
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Targeting Pim Kinases and DAPK3 to Control Hypertension.
Sustained vascular smooth muscle hypercontractility promotes hypertension and cardiovascular disease. The etiology of hypercontractility is not completely understood. New therapeutic targets remainExpand
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Stochastic detection of Pim protein kinases reveals electrostatically enhanced association of a peptide substrate
Significance The modulation of ionic current flowing through an individual pore can be used for the stochastic sensing of a wide variety of analytes. Here we have produced protein pores by insertingExpand
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Effect of Single Amino Acid Substitution Observed in Cancer on Pim-1 Kinase Thermodynamic Stability and Structure
Pim-1 kinase, a serine/threonine protein kinase encoded by the pim proto-oncogene, is involved in several signalling pathways such as the regulation of cell cycle progression and apoptosis. ManyExpand
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Pim Kinase Inhibitors Evaluated with a Single-Molecule Engineered Nanopore Sensor.
Protein kinases are critical therapeutic targets. Pim kinases are implicated in several leukaemias and cancers. Here, we exploit a protein nanopore sensor for Pim kinases that bears a pseudosubstrateExpand
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Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics.
We present an analysis of intracellular metabolism by non-targeted, high-throughput metabolomics profiling of 18 breast cell lines. We profiled >900 putatively annotated metabolite ions for >100Expand
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Single-Molecule Protein Phosphorylation and Dephosphorylation by Nanopore Enzymology.
Reversible protein phosphorylation plays a crucial and ubiquitous role in the control of almost all cellular processes. The interplay of protein kinases and phosphatases acting in opposition ensuresExpand
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1 Type II inhibitors targeting CDK 2
Kinases can switch between active and inactive conformations of the ATP/Mg binding motif DFG which has been explored for the development of type I or type II inhibitors. However, factors modulatingExpand
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