Leila Satarian

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BACKGROUND This study aims to differentiate human induced pluripotent stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a demyelinated optic chiasm model in rats. METHODOLOGY/PRINCIPAL FINDINGS We generated a cell population of oligodendrocyte progenitors from hiPSCs by using embryoid body formation in a defined(More)
BACKGROUND inefficient remyelination of demyelinated plaques in multiple sclerosis (ms) leads to secondary axon degeneration and progressive disability. therapies that potentiate remyelination would be of immense help for managing MS. OBJECTIVE Here, we report the effects of valproic acid (VPA) on focal experimental autoimmune encephalomyelitis (fEAE). (More)
Introduction: Regulators of G-protein signaling protein negatively control G protein -coupled receptor signaling duration by accelerating Gα subunit guanosine triphosphate hydrolysis . Since regulator of G-protein signaling4 has an important role in modulating morphine effects at the cellular level and the exact mechanism(s) of adrenalectomy-induced(More)
Activation of hypothalamic-pituitary-adrenal (HPA) axis inhibits development of morphine tolerance. Also, the expression of CaMKIIalpha is increased following chronic administration of morphine. In the current study, we tried to examine the effect of epinephrine, on the development of morphine tolerance; and also evaluate the expression of CaMKIIalpha as a(More)
Chronic morphine leads to dependence, tolerance, and neural apoptosis. Vitamin C inhibits the withdrawal syndrome in morphine-dependent subjects and prevents apoptosis in experimental models. Sodium-dependent vitamin C transporter (SVCT) type-2 is the main transporter for carrying vitamin C into the brain and neural cells. The mechanism(s) by which vitamin(More)
BACKGROUND Degeneration of retinal ganglion cells (RGCs) is a common occurrence in several eye diseases. This study examined the functional improvement and protection of host RGCs in addition to the survival, integration and neuronal differentiation capabilities of anterior specified neural progenitors (NPs) following intravitreal transplantation. (More)
Direct conversion of somatic cells into neural stem cells (NSCs) by defined factors holds great promise for mechanistic studies, drug screening, and potential cell therapies for different neurodegenerative diseases. Here, we report that a single zinc-finger transcription factor, Zfp521, is sufficient for direct conversion of human fibroblasts into long-term(More)
Introduction: There is some evidence supporting the reduced activity of integrins following chronic administration of morphine. This reduction might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes them to be activated. The effect of integrins activation using manganese on tolerance(More)
The generation of retinal pigment epithelial (RPE) cells from pluripotent stem cells is a topic of interest over the past few years as dysfunctional RPE cells are a primary cause of ocular diseases. However, a number of obstacles need to be overcome before these cells can be used in clinical trials. This review aims to provide an overview of the latest(More)
Demyelination as the main hallmark of multiple sclerosis (MS) is caused by immune cells activation against the myelin of the central nervous system (CNS). Demyelination disrupts the nerve signal transmission and eventually results in axonal degeneration (Radtke et al., 2007). Myelin repair or remyelination occurs in almost newly affected patients as a(More)