Leighton Scott

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BACKGROUND Neural cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) have been implicated in both the fasciculation and guidance of axons, but direct genetic evidence of a role for neural IgCAMs in axon guidance in vertebrates is lacking. The L1 subfamily of vertebrate neural IgCAMs function as both homophilic and heterophilic receptors for(More)
To study the fate of the yolk glycoproteins found in eggs and embryos of the sea urchin, Strongylocentrotus purpuratus, a polyclonal antibody to a 90-kDa polymannose glycoprotein found in the embryo was prepared. Immunoblot analysis of total proteins over the course of development showed that this antibody recognized a family of glycoproteins. Concomitant(More)
The fate of the yolk platelets and their constituent yolk glycoproteins was studied in Strongylocentrotus purpuratus eggs and embryos cultured through the larval stage. Previous studies have shown that the yolk glycoproteins undergo limited proteolysis during early embryonic development. We present evidence that the yolk glycoproteins stored in the yolk(More)
The sea urchin Heliocidaris tuberculata undergoes typical development, forming an echinoid pluteus larva, whereas H. erythrogramma undergoes direct development via a highly modified, nonfeeding larva. Using a polyclonal antibody prepared against yolk glycoproteins from the typical developer Stronglyocentrotus purpuratus, we found that H. tuberculata(More)
OBJECTIVE To examine the incidence of premature luteinization in individuals undergoing hMG with IUI therapy, the association between premature luteinization, cycle fecundity, and pregnancy outcome, and to determine if the selective use of leuprolide acetate (LA) in women demonstrating premature luteinization improves pregnancy outcome in subsequent hMG(More)
OBJECTIVE To evaluate the benefit of increasing the hMG dose in subsequent superovulation cycles for those individuals who demonstrate a poor response on up to three ampules of hMG daily. DESIGN AND SETTING Retrospective analysis of all superovulation cycles at the University of Connecticut Health Center. PATIENTS All women undergoing hMG therapy with(More)
Present Condition.?He is extremely weak, thin and ansemic, and has the appearance of being in continual pain. His urine is foul and contains pus. He has a small sinus opening at the apex of Scarpa's triangle 011 the front of the right thigh. A probe passes upwards along the sinus through the obturator foramen just behind the ascending ramus of the os pubis(More)
a systolic murmur at the base. I traced it upwards and found it loudest beneath the outer half of the right clavicle. Here it was very loud, and with it were very marked thrill and pulsation. I also heard it along the brachial artery as far as the elbow. Was it aneurism ? I found the same condition on the left side. I told the man to drop his shoulders, and(More)